My 10 week old has reflux and has been on Zantac since week two. We usually give her the dose approximately 20 minutes before feeding and recently, in the last three weeks or so, she has started throwing up a significant portion of the meal. This only happens after being dosed - the rest of the day, she keeps everything down except for the normal spitting up associated with reflux. It doesn't happen every time she takes the medicine, maybe every other day or third day, but often enough that it seems to be related.
The evening dosage is usually given before her last meal before bed, which is typically a bottle of expressed milk. The morning dosage is given after she wakes up, ~20 minutes before being breastfed. After the bottle feeding, she throws up most of what she eats - we thought maybe the bottle feeding was what was causing it, maybe she was eating too much too fast but she only has this problem after Zantac. And she also spits up a significant amount after Zantac + breastfeeding, a lot more than at any other time of the day.
Has anyone else experienced this reaction to Zantac? Our ped said he'd never heard of anything like this and didn't seem worried, since she's gaining weight. I should mention that she is only vomiting undigested milk, not bile or anything worse, and that she doesn't appear to be in any pain and is fine right after - she'll even eat again and keep it down. It just seems like the Zantac is inducing this somehow... I know it's mostly a laundry problem but it just kills me to see her vomiting and I know it can't be comfortable, even if it's not a health issue.
Mom to Georgia, dob 5/31/10
11 lbs 12 oz, 22.5" at nine weeks