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Thread: help! Pinworm medications ick!

  1. #1
    Join Date
    Oct 2007
    Posts
    32

    Question help! Pinworm medications ick!

    My 3 year old has pinworms and we all have to take medications in the family!
    ANYONE had this problem while nursing a 6 month old?
    ANYONE taken Vermox or know if this is ok for nursing moms? (pharmacist said their were no studies she knew of)
    ANYONE had to medicate their 6 month old? (dr. would rather not right now - phew! -- but only if not small white rice in stool -- which sounds a lot like the seedy things I see all the time so I have to run and dig up some sirties, oh joy)

    I feel so bad for trying to make her sleep through the night and I thought the itches were just one more procrastination technique!!


  2. #2
    Join Date
    Dec 2006
    Posts
    139

    Default Re: help! Pinworm medications ick!

    According to http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT

    you should be OK, but double check with Dr. to be 100% sure

    Mebendazole
    CASRN: 31431-39-7
    For other data, click on the Table of Contents


    Drug Levels and Effects:


    Summary of Use during Lactation:
    Limited data indicate that mebendazole is poorly excreted into breastmilk. Because mebendazole is virtually unabsorbed orally it is unlikely to adversely affect the breastfed infant or milk production.


    Drug Levels:
    Maternal Levels. One author reported information received by personal communication from the manufacturer stating that after a single 100 mg oral dose of mebendazole to a nursing mother (time postpartum not stated), the peak milk level was 6 mcg/L. Mebendazole was no longer detectable (<1 mcg/L) in milk 13.25 hours after the dose.[1]

    One woman was given mebendazole 100 mg orally twice daily for 3 days beginning the first day postpartum. Mebendazole was measured in milk following treatment (exact timing not stated). Mebendazole was undetectable (<20 mcg/L) in milk. The authors stated that this value was in agreement with those reported by the manufacturer and that the infant probably absorbed negligible mebendazole from breastmilk.[2]

    Infant Levels. Relevant published information was not found as of the revision date.


    Effects in Breastfed Infants:
    Relevant published information was not found as of the revision date.


    Possible Effects on Lactation:
    A nursing mother who was 13 weeks postpartum was taking oral metronidazole 250 mg three times daily. Milk production seemed to be unaffected. On the eighth day of therapy she passed a roundworm. Metronidazole was discontinued and oral mebendazole 100 mg twice daily was started. The patient was "tense" for a few days after passing the worm. On the second day of mebendazole treatment, milk production dropped markedly and she began supplementation with formula. By day 7, milk production had ceased. The authors suggested that mebendazole might have caused the drop in milk production, but offered no further evidence other than the temporal relationship.[3]

    Four patients were treated with oral mebendazole 100 mg twice daily for 3 days beginning the first day postpartum. Two had pinworm (Enterobius), 1 had roundworm (Ascaris) and 1 had hookworm (Ancyclostomia) infestations. All breastfed successfully.[2]

    One author reported information received by personal communication from the manufacturer stating that no inhibition of lactation was noted after a single 100 mg oral dose of mebendazole to a nursing mother (time postpartum not stated).[1]


    AAP Category:
    Not listed.


    Alternate Drugs to Consider:
    Albendazole


    References:
    1. Stoukides C. Can a mother safely breastfeed while on mebendazole (Vermox)? J Hum Lact. 1994;10:269. PMID: 7619284
    2. Kurzel RB, Toot PJ et al. Mebendazole and postpartum lactation. N Z Med J. 1994;107:439. Letter. PMID: 7970347
    3. Rao TS. Does mebendazole inhibit lactation? N Z Med J. 1983;96:589-90. Letter . PMID: 6575310



    Substance Identification:


    Substance Name: Mebendazole

    CAS Registry Number: 31431-39-7

    Drug Class:
    Anti-Infective Agents
    Antiparasitic Agents
    Antinematodal Agents

    Administrative Information:


    LactMed Record Number:
    465


    Last Revision Date:
    20071227

    Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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