Zantac and reflux meds are one of those things that you just have to try for a few weeks to see if they help your LO. They take awhile to build up in the baby's system and start working really well.
We've had wonderful experience w/Zantac as Logan is a silent refluxer. The only drawbacks are that it tastes really bad (he's used to it now) and you have to keep adjusting the dose according to weight.
It really made my son a much happier person and turns out that his 'colic' was really reflux and I'm okay with him taking the medication.